Endocrine Abstracts

Introduction: Gynecomastia is a benign proliferation of the human mammary gland that results from an imbalance between androgens and estrogens. It can be physiological at different stages of life (birth, adolescence, senescence) or secondary to drugs or diseases leading to androgen decline or estrogen elevation. We report a case of an important gynecomasty in a 5 year old boy.Case report: A boy 5-year-old with no medical history consulted for a gynecomas...

Introduction: Cushing’s disease (CD) is associated with metabolic and cardiovascular comorbidities that can be incompletely resolved after disease remission. Our objective was to evaluate the metabolic and cardiovascular status of patients with MC in remissionPatients and methods: We performed a retrospective study including 15 CD patients cured by pituitary surgery. Patient’s medical records were reviewed and information regarding blood pressu...

Background: Antithyroid drugs (ATD) are indicated as first intension in the treatment of Graves’disease (GD). Only two molecules are marketed in Tunisia: Benzylthiouracil (BTU) and Methimazole (MMI). There is still no clear conclusion about the choice of appropriate drug. Our objective was to compare the MMI treatment with the BTU in terms of efficacy and adverse effects (AEs).Methods: It’s a retrospective study. We studied patients with a firs...

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that result from the deficiency of one of several enzymes involved in the steroidogenic pathway for cortisol biosynthesis. The most common cause of CAH, accounting for 90% of cases, is 21-hydroxylase deficiency. The symptoms of disease very depending on the nature and severity of the enzyme deficiency as well as the sex of the individual. Non-classical CAH is generally late onset. Ho...

Background: Physical activity is associated with several health benefits, including lower obesity and diabetes risk. Many different factors influenced physical activity patterns of adolescents in a complex interactive way. The aim of this study was to assess association between physical inactivity and socioeconomic factors and lifestyle among Tunisian adolescents.Methods: A cross-sectional study was carried out in Sousse, Tunisia during the school year 2...

Introduction: Central diabetes insipidus (CDI) is a heterogeneous condition characterized by the presence of polyuria and polydipsia due to a deficiency of arginine vasopressin. Frequently, CDI is wrongly considered idiopathic if not associated with other signs and symptoms.Case report: We report the case of a 50-year-old woman diagnosed with idiopathic central diabetes insipidus at the age of 34. The MRI scan of the hypothalamus and pituitary gland was ...

Introduction: Acromegaly is a chronic disorder usually caused by growth hormone (GH)-secreting pituitary adenomas. Transsphenoidal surgery remains a treatment of choice for restoring GH to normal levels. The aim of this study was to illustrate the relationship between some factors and transsphenoidal surgery outcomes.Patients and methods: We retrospectively analysed the outcome of 31 patients with acromegaly after initial endoscopic transsphenoidal surge...

Introduction: Hidradenitis suppurativa (HS), also known as acne in-versa is a chronic inflammato-ry dermatosis. Emerging evidence suggests that HS is associated with other comorbidities, while data concerning the coexistence of HS and Down syndrome (DS) are scarce. We report the case of a young male affected by DS and HS that suffers from multiple endocrine disturbances.Observation: A 23-year-old overweight male (BMI 32 kg/m2) with a 9-year hi...

Background: Although the issue of cardiovascular complications in type 2 diabetic patients is widely discussed and recommendations for such screening are known, it is less common to do so for type 1 diabetes mellitus (T1DM). Unfortunately, the mortality rate due to vascular complications is higher among type 1 diabetic patients than in the general population.Patients and methods: Seventy-six patients with T1DM history over 20 years were included in our s...

Background: Patients with type 2 diabetes mellitus (T2DM) have a greater risk for cardiovascular morbidity and mortality than those without T2DM. This risk is even further aggravated if they also suffer from hypertension and/or dyslipidaemia. However, better cardiovascular outcome can be reached by tight control of blood glucose, serum lipids, and blood pressure (BP).Patients and methods: One hundred and nineteen patients were consecutively enrolled. Wel...